#59. Neuromodulators as Peril Specialists [neuroscience, evolution]

NE   EV

Red: theory; black, fact

Solanum dulcamara, a plant with anticholinesterase activity.

“Life is difficulty.” -The Buddha Gautama

My PhD thesis was about a neuromodulator (acetylcholine) acting on mammalian brain. It was tough to decapitate so many rats; I never got used to it.

The basic theory

I conjecture that the primordial function of any type of transmitter substance acting on the g-protein-coupled cell-surface receptors or nuclear receptors of neurons was to coordinate the whole-organism response to some class of perils.

Table 1.

Peril	Substance	Failure mode
Extremes of heat and cold	glutamate and GABA	?
Predator	serotonin	depression
Parasite	histamine	phobia
Rival conspecific	noradrenaline	paranoia
Social isolation

#58. Is the Theory of Everything Like This? [physics]

PH

Red, theory; black, fact

Recursive.

The picture appears to contain a diagonal line, but if you look closely, you will see that nowhere is there a diagonal line. This picture was created by a simple recursive algorithm, and the disappearing diagonal is formed by successive approximations. 

In theorizing, then, you keep applying the same principle to the result of its previous application. Example: gravity makes a molten ball orbiting the Earth, namely the early moon, and then that same gravity brings meteorites down on the resulting smooth surface of basalt and anorthosite to create the pattern of craters we observe. Example: the evolution of evolution; all the molecular apparatus of evolution lies within the scope of that same evolution. Example: What if a quantum vacuum fluctuation happens in the background of a previous fluctuation? Did such a recursion create the observable universe?

#57. The Drill Sergeants of the Apocalypse [evolutionary psychology, population]

PO     EP

Red, theory; black, fact

Till Eulenspiegel, a classical trickster in European cultures

The trickster type may really be Nature's penetration tester who tests our defences against adversity. 

The type probably emerges in contexts of unequal power (Person A has the shotgun; person B doesn’t). Thus, an abiding fear is the soil out of which tricksterism grows, by the following positive feedback: A successful trick shows up the more powerful persons and shows them in a feckless light, which reduces the fear level of the trickster, which reinforces trick-playing. This is a short-term high that comes at the expense of worse relations with the more powerful persons and thus eventually even greater fear levels for the tricksters, which they try to remedy with still more tricks. An example of an unequal power relationship is between a foreign invader and the defenders. Invasion is such a common event in history that by now, countermeasures will have evolved. Tricksterism is likely to be a tile in the mosaic of any such adaptation. 

Tricksterism also seems to be a form of play. A result from animal ethology is that the play of young animals is a form of learning. The thing learned in playing tricks may be how to manage power inequalities.

A biological precedent for penetration testing?

Evidence for a biological precedent may be the many retroviruses integrated into the human genome. One of these may become active now and then at random and kills the host cell if the anti-viral defences of the latter have become weak due to some somatic mutation. The red team-blue team strategy seems to be too good a trick for nature to miss.

Evolution of the trickster

Modern human populations may have two independent axes of political polarization: oppressor-oppressed and trickster-control valuer. The first may subserve dispersal by generating refugee groups and the second may subserve building. Any built thing must serve in a complex world in which many constraints must be simultaneously observed. Thus, after the initial build, a long period of tweaking must typically follow. The role of the tricksters is to powerfully motivate this tweaking, for example, by cleverly making someone’s shelter fall down, before the complacency of the control-valuer builders leads to disaster. This may have been how engineering was done by an archaic version of Homo sapiens. Tricksterism may have evolved out of a previously evolved capacity for military strategy, which involves essentially putting one over on the enemy. 

Tricksterism today

The tricksters can also make mistakes, causing damage that cannot have a silver lining in any possible world, and moving to correct this is a natural role of the builders. If you are a builder, ask this: “What is the best use of my indignation?” It is to keep to a strict harm-reduction approach. 

Tricksterism can intensify into sadism, in which the protagonist takes pleasure in the victim’s torment and wants to make it last. However, if you make it last, you are giving the victim plenty of time and motivation to figure out solutions, like a patient old instructor giving his pupil his lessons one at a time, as he is ready for them, and this is how the wise victim will construct the situation. Such a victim will end up with information and know-how others will pay for. 

Before the trickster

Our evolutionary forebears may have been champion dispersers for a long time before the ice age forced some of them to become champion builders, initially, of shelters and warm clothing. (Champion environment modifiers may be closer to the mark.) It is an interesting fact that physically, humans exceed all other animals only in long-distance running, which can be read as dispersal ability. Our carelessness with preserving the local environments and our propensity for overpopulation can be read as typical r-selected disperser behavior. The r-selecting niche may have been big game hunting. H. erectus sites indicate consumption of medium and large meat animals. Overhunting would have occurred routinely, due to the slow reproduction rates of large animals and the high hunting efficiency of H. erectus due to tool use, so that dispersal of the hunters to new habitats would likewise have been routine.

Picture credit: Wiki Commons

#56. Stress and Schizophrenia [neuroscience]

NE

Red, theory; black, fact

Introduction

The main positive symptoms of schizophrenia, namely hallucinations, word salad, and loosening of associations, all seem to be variations of the latter, so loosening of associations will here be taken as the primary disorder. Stress and the brain's dopaminergic system are strongly implicated in the causation of schizophrenia. In connection with stress, psychologists speak of "the affective [emotional] pathway to schizophrenia." 

Organismal responses to stress

Stress is known to increase genetic variability in bacteria, a process known as transformation. Stress is likewise known to increase the meiotic recombination rate in sexually reproducing organisms such as fruit flies. (Stress-induced recombination and the mechanism of evolvability. Zhong W, Priest NK. Behavioral ecology and sociobiology. 2011;65:493-502.) It seems that when an organism is in trouble, it begins casting about ever more widely for solutions. If evolution is the only mode of adaptation available, this casting about will take the form of an increase in the size and frequency of mutations. In conscious humans, however, this casting about in search of solutions in the face of stress may well take the form of a loosening of associations during thought. Should the person find the solution he or she needs, then presumably the stress levels go down and the thought process tightens up again, so we have a negative feedback operating that eventually renormalizes the thought process and all is well. In optimization theory, this process is called "simulated annealing."

Disorder of a cognitive stress response

But what if the person does not find the solution they need? Then, presumably the loosening of associations gets more and more pronounced ("reverse annealing") until it begins to interfere with the activities of daily living and thus begins to contribute net stress, thus making matters worse, not better. Now we have a pernicious positive feedback operating, and it rapidly worsens the state of the sufferer in what is known as a psychotic break, resulting in hospitalization. That these psychotic breaks are associated with tremendous stress is made clear by the fact that post-traumatic stress disorder is a common sequel of a psychotic episode.

 

Stress: molecular aspects

Messenger substances (i.e., hormones and neuromodulators) known to carry the stress signal are: CRF, ACTH, cortisol, noradrenaline, adrenaline, dopamine, NGF, and prolactin. The well-known phenomenon of stress sensitization, which may be part of the disease mechanism of schizophrenia, probably inheres in long-term changes in protein expression and will not be apparent in a simple blood test for any of the above substances without a prior standardized stress challenge. (e.g., the process of getting the needle itself. In that case, you would install a catheter through the needle to permit repeated blood sampling and collect the baseline sample long after the intervention sample, not before, as is customary in research.)

Other mental illnesses

Bipolar disorder may result from an analogous positive feedback affecting another problem solving adaptation of the brain, which would be modelled by the alternation of brainstorming sessions (mania) with sessions in which the brainstormed productions are soberly critiqued (depression).

Brain mechanisms

How does the loosening of associations of schizophrenia arise? I conjecture that one activated sensory memory represented in the posterior cortex does not activate another directly, but indirectly via an anatomically lengthy but fast relay through the prefrontal cortex, which has a well known dopaminergic input from the ventral tegmental area of the midbrain. A higher vertebrate may have a free-will spectrum, with machine-like performance and high dopaminergic tone at one end, and at the other, a carefully considered performance verging on overthinking, with low dopaminergic tone. Persons with schizophrenia have pushed past the latter end of the spectrum into dysfunction. Dopamine could orchestrate movement along the free-will spectrum by a dual action on the prefrontal cortex: inhibiting associational reflexes passing back to posterior cortex while facilitating direct outputs to the motor system. Dual actions of neuromodulators are a neuroscientific commonplace (e.g., my PhD thesis) and dopamine is a neuromodulator. The NMDA receptor, which is also strongly implicated in schizophrenia, enters the picture as the source of excitation of the ventral tegmental area.

Photo by Ameer Basheer on Unsplash

#55. Gender is Pecking Order [evolutionary psychology]

EP

Red, theory; black, fact

Gender is pecking order

Gender, social status, and testosterone are clearly interrelated, but exactly how requires clarification when the very nature of gender is in question, as now. One possibility is that the male pecking order sits directly atop the female pecking order, and there is no barrier between. Thus, a male who falls low enough in the male pecking order will undergo a reversal in gender identification from male to female (and maybe keep on going down) and a female who rises high enough in the female pecking order will likewise undergo a reversal in gender identification from female to male (and maybe keep on going up). The entire structure could be called "the" pecking order, with the statistical median of the status ranks, and possibly the ranked testosterone levels, always dividing females from males, at least in terms of gendered social signaling. This could be an example of what is called an exact theory replacing its approximate counterpart. In this case, the corresponding approximate theory would be the gender binary. ("You are either a man or a woman.") 

A limitation of this “median theory” is that no causative mechanism is provided.

Recent history of trans

Since the early Sixties, we have seen a trend of increasing media exposure of trans and non-binary individuals, and this was also a period of ever-increasing human population numbers. I conjecture that the latter trend caused the former. The population trend may have produced an upward trend in the average population density at which people are living, suburban expansion notwithstanding. This may have caused an increasing incidence of aggressive one-on-one interactions among humans due to the Calhoun effect, which is much discussed in these pages. See post #36. Aggressive, one-on-one interactions are well known to change the social status of the combatants, the winner enjoying increased status (i.e., a higher ranking in the pecking order) and the loser suffering reduced status. Overall, population density increases can thus be expected to increase the amount of traffic on the social ladder, both upward and downward, leading to increasing numbers of individuals crossing the median and becoming trans or nonbinary. The increasing numbers of trans and nonbinary individuals in society was then faithfully reflected in the content of the news stories of the day. QED.

Trans not genetically determined

Consistent with this, PLOS blogger R. Lewis, who has a PhD in genetics, found remarkably little evidence of a direct genetic causation in transgenderism. Moreover, out of 58 studies on "transgender" listed on clinicaltrials.gov, nothing worth mentioning was found about genetics. This could be an instance of the filing-drawer effect (negative results not published but left to languish in the filing cabinet).

How pecking-order dynamics may lead to dispersal and a mechanism 

I am indebted to Jordan Peterson for turning me on to the pecking-order idea. It can explain aspects of dispersalism, as follows: If people have no emotional memory of their social wins and losses, we would expect their distribution on the social ladder to be Gaussian (aka, a bell curve). However, if a win or loss leaves you with an emotional residue of optimism or pessimism (and, of course, it does), a positive feedback can set in if conflicts are coming faster than the emotional fallout from each can dissipate, so that the more you lose, the greater your pessimism, and the more likely you are to lose in the future. Moreover, the more you win, the greater your optimism, and the more likely you are to win in the future. (Following Peterson, this emotional fallout effect may be due to prolonged up- and down-regulations of serotonin concentrations in the brain.) This dynamic then splits the population into a bi-modal social distribution, resulting in dispersal when most of the underdogs become refugees. Those who remain conceal their potential to reproduce (and thus compete) in gay-trans relationships. The frequency of conflicts could be measuring population density, and the conflicts would not necessarily be over resources, but over proxies for these such as land or jobs. With the addition of these ideas, the splitting and separation of overcrowded rodent populations in the behavioral-sink phase of a Calhoun experiment is explained. To connect these ideas with my earlier idea of the sadness cycle, I conjecture that sadness and its attendant social signaling expresses anger colored by pessimism about winning, whereas contempt and its social signaling expresses anger colored by optimism about winning.

 

Photo by Jonny Gios on Unsplash

# 54. Disaster Biology [evolution, evolutionary psychology]

EP    EV 

Red, theory; black, fact

The habitat may have been a unit of selection in early hominins, leading to group selection, and much of our evolution may have proceeded by an accumulation of founder effects.

Opportunities for colonization of recently-emptied habitats are ephemeral. Under disaster-prone conditions, this plausibly leads to selection pressure for migrant production and evolvability (i.e., a high rate of evolution, especially founder-effect evolution).

Language diversification in humans may be an evolvability adaptation. Language diversity would work by preserving genetic founder effects from dilution by late-coming migrants, whose reproduction would be held back by the difficulties of learning a new language. Xenophobia and persistent ethnicity markers can be explained in the same way. The spread of linguistic and cultural novelties in a hominin population is predicted to be especially fast in newly colonized, previously empty habitats. Alternatively, the linguistic novelties may start as a thick patois developed by an oppressed group in the home habitat prior to becoming refugees, as a way to make plans "under the noses" of the oppressing group.

Refugee-producing adaptations sub-serving dispersal can be called "tough altruism." Populations producing more refugees are more likely to colonize further empty habitats, a selective advantage.

Disaster biology may be what is conceptually missing from theories of the origin of life (abiogenesis). i.e., the forerunners of the first cells may have been spores that formed by budding from the surface of bodies of water.

Photo by Purnomo Capunk on Unsplash

#53. Where are All the Space Aliens? [evolution, evolutionary psychology]

EP    EV

Red, theory; black, fact

Canada's remote Algonquin Radio Observatory,

which took over SETI duty between 1988-91.

Astronomical observations and the Fermi paradox

Contemporary exoplanet research keeps turning up extra-solar-system planets that seem to be promising abodes of life of the Earthly variety (never mind the completely weird biochemistries that may exist on other planets). In the habitable exoplanets catalogue (HEC), kept by the Planetary Habitability Laboratory, University of Puerto Rico, Arecibo, the list of planets found orbiting in the conservative habitable zone now has 17 entries, and a 2013 paper by Petigura et al. ("Prevalence of Earth-size planets orbiting Sun-like stars") placed the percentage of stars in our galaxy with potentially habitable planets at 22 ± 8. Accumulating evidence suggests that life is common in our galaxy, yet SETI research—the search for extraterrestrial civilizations that send out radio signals that bear some stamp of intelligence—has drawn a complete blank, as far as I know. And if it did find something, it would make such a sensation in the media that no-one could help knowing. So I ask you: where are all the space aliens? This question is generally attributed to 20th-century physicist Enrico Fermi and has since become known as the Fermi Paradox.

My hypothesis is this:

Life is one thing; intelligent life is quite another. This is a form of the Rare Earth hypothesis, which is one of the avenues that has been explored through the years in the search for a resolution of the Fermi Paradox.

Biospheres may not be permanent 

No doubt there are many, many planets in our part of the galaxy that have some form of primitive life, and many, many more "graveyard planets" that once had life but are now sterile. Mars may well be an example of this kind of planet in our own solar system.

Biochallenge!

I conjecture that if we seem to be alone in this part of the galaxy, based on the negative SETI evidence, it is because we are, and this is because we have evolved to the level of intelligence first in this galactic neighborhood, because evolution on the Earth is egregiously rapid. It has taken us four billion years to get this far, which doesn't sound so fast, but everything is relative. This rapid evolution is plausibly a response to challenges: all the various natural disasters we are subject to here on Earth, examples being bolide (meteor) crashes, continental glaciations, drifting continents, droughts, earthquakes, floods, hurricanes, long climatic warm spells, tornadoes, tsunamis, volcanism, wild weather, wildfires, and winter.

Sept 23, 2018: Tornadoes knock out primary transformer station in my town.

Case in point: a large bolide strike is believed to have triggered the extinction of the dinosaurs, making way for the rise of the mammals, and we ourselves are the descendants of those mammals. The bolide may have killed the dinosaurs indirectly, by touching off a climate shift in our dangerously unstable world. This would explain the temporary presence of dinosaur fossils above the Cretaceous/Tertiary iridium anomaly, which has been a problem for the bolide hypothesis.

Case in point: the rise of modern humans seems to have coincided with the end of the last continental glaciation. The rigorous, cold-climate conditions prevailing then might have selected our ancestors for high ability in building shelters and sewing protective clothing. These skills might have required the rapid evolution of a high ability to process spatial information, which we then leveraged into the building of civilizations upon the return of temperate climatic conditions.

To contrive a planet that is so challenging and difficult, yet has not succeeded in destroying life altogether in four billion years, may require a very rare combination of parameters (e.g., our distance from the sun, the size and composition of the Earth, the presence of the asteroid belt, the presence of the Oort cloud), and this rarity has led to our emerging into intelligence before it happened anywhere else in this part of the galaxy.

These parameters may well have special values at which critical behavior occurs, such as the onset of positive feedbacks leading to heating or cooling. Earth may be simultaneously close to several of these critical points, a rare circumstance, but one that does not require extreme, atypical values of any given variable.

My take on the Rare Earth hypothesis therefore emphasizes what are called "evolutionary pumps" (e.g., glaciations, bolide crashes, etc.) in discussions of this hypothesis, as well as the anthropic principle. 

August 28, 2011: An Ottawa sunset inflamed by a recent hurricane in the USA.

Evolution

I further conjecture that the difficulties of our past have left their mark on us, and we call it "evil." Some will deny that this concept has any construct validity, saying, "It's not a thing," but I think that it is an approximate version of something that does, which I term "dispersalism" in this blog. This is because a basic strategy for surviving disasters is dispersal. 

Our planet's predilection for disaster has deeply ingrained dispersal tendencies into most species here, by the mechanism of natural selection. Humans now get their food from agriculture. However, agriculture requires a settled existence and is therefore in opposition to dispersal, so the plot thickens.

This characteristic of agriculture results in the psychological pressure for dispersal relentlessly building, pressure-cooker fashion, across time, until a destructive explosion occurs (war or revolution), thereby accomplishing the long-delayed dispersal.

Wildfire smoke seen in Ottawa, Jun. 2023