Showing posts with label pharmacology. Show all posts
Showing posts with label pharmacology. Show all posts

Friday, June 1, 2018

#40. The 1950 Ramp [population, genetics, evolutionary psychology, engineering, neuroscience]

PO     EN     EP     NE     GE     
Red, theory; black, fact.

6-01-2018; 
Since about 1950, the world population has been increasing along a remarkably steady ramp function with no slackening in the rate of increase yet apparent, although one cycle of oscillation in the slope occurred during the Sixties. Malthusian reasoning predicts an exponential increase, which this is not. From several lines of evidence, I keep coming back to the idea that humans must have a subconscious population controller in their heads, and yet such a controller would have leveled out the increase by now. Until now, no theory has sufficed to explain the facts.

I here propose that the natural population curve for humans in good times is a saw-tooth waveform, with population ramps alternating with political convulsions that result in a large group being expelled permanently, resulting in the precipitous but limited drop in local population density that ends the saw-tooth cycle. This cycle accomplishes the ecological dispersal function to which I allude many times in these pages. The population must ramp up for a time to sustainably create the numbers needed for the expulsions. The WHO population curve shows only a ramp because it is a worldwide figure and therefore population losses in expelling regions are balanced by population increases in welcoming regions. This also implies that human population has been increasing in a way unrestrained by food or resource availability or any other external constraint since 1950, to now.

Clearly, human population is being controlled by instinctive factors, but not to a constant absolute density, but rather to a constant rate of increase. Population density would go up along the much faster, steeper, and more disastrous exponential curve of Malthus if there were actually no controller.

My formal training in engineering and neuroscience justifies a bit of speculation as to mechanisms at this point. Look first for such a controller in the hypothalamus, already known to control other variables, such as temperature, by feedback principles.

In school, I was taught that nature does not reinvent the wheel, which I understand to mean that once a brain structure evolves to serve a particular computational function, it will be tapped for all future needs for such a calculation. This process may make it grow larger or develop sub-nuclei, but additional, independent nuclei for the same computation will never evolve.

I will continue to assume that the controller is a conventional PID controller, as in previous posts. To make it control rate of increase rather than absolute population density, you put a differentiator in the feedback pathway. Look first in the amygdala for such a differentiator. If you are of the opinion that human population control is urgent, then you must knock out this differentiator and replace it with a simple feed-through connection. Fortunately, one common way for evolution to implement differentiation in mammals is to begin with such a feed-through connection and supplement it with an inhibitory, slow, parallel feed-forward connection. If this is the case here, then you just inhibit the feed-forward pathway pharmacologically as specifically as may be, and the job is done. Subjectively, the effect of such a drug would be to take away people's ability to get used to higher population density in deciding how many children to have. An increased propensity to riot should not occur.

I assumed in the last post that the political convulsions that produce dispersal are triggered by the value on the integrator of the PID controller rising above a threshold. However, in the above design solution, the convulsion would be triggered by the raw, undifferentiated population-density signal rising above some threshold. Look in the amygdala for this signal as well. Consistent with this, bilateral removal of the amygdalae and hippocampi in monkeys is known to have a profound taming effect accompanied by hypersexuality, known as the Kluver-Bucy syndrome.

6-17-2018: To be consistent, I would have to say that the differentiator for the population signal is more likely to be in the hippocampal formation by the argument of nature not reinventing the wheel, because in an earlier post, I interpreted the hippocampus as the site of four successive differentiations that carry out a Fourier transform by mapping sinusiodal waves back onto themselves at a particular best frequency, in the presence of a map of such best frequencies.

However, this setup would require the creation of two neuron-to-neuron connections for its evolution; a first connection to send the amygdalar raw population signal to the hippocampus, and a second to send the differentiated result back for further processing. At best, this would require two simultaneous mutations. Either change by itself would be at best useless and could never be selected. This appears to be another example of irreducible complexity requiring the bi-mutation mechanism described in the previous post. 

The mechanisms usually offered to explain cases of apparent irreducible complexity, such as spandrelling, exaptation, and scaffolding, all appear to lack time efficiency and processiveness. I previously said that in evolution there are no (absolute)  deadlines, but relative deadlines can easily be created by an interaction of processes. In the presence of relative deadlines, such as adaptive footraces to be the first clade to exploit a newly-habitable area or a new niche, time is of the essence and selection for speed and evolvability can be expected. Such selection will create mechanisms such as crossing over that enhance evolvability.

Saturday, March 17, 2018

#37. Two Kinds of War [evolutionary psychology, engineering, neuroscience]

EN     EP     NE     
Red, theory; black, fact.

3-17-2018: In my post "The Pilgrim and the Whale", I propose that much human conflict sub serves dispersal.

12-28-2017: There are probably two basic biological uses for human anger, the other one being an emergency brake on population increase that avoids Malthusian disasters by triggering wars. This kind of war ends life without being notably efficient in producing mass migration. This is the use discussed in my post "The Iatrogenic Conflicts of the Twentieth Century." Mention of the destruction of Coventry was struck out because it looks better suited to population reduction than to triggering mass migration.

3-12-2018: I have long wondered why the Four Horsemen of the Apocalypse seem to include two gentlemen both in charge of warlike matters. Why the apparent duplication? The above postscript may give the reason: one (the guy with the bow) represents wars of (absolute) depopulation and the other (the guy with the sword) represents wars of displacement (relative depopulation).

The Coventry Blitz did, however, produce so much mass migration into the countryside surrounding that city that it was an embarrassment for the British government, calling into question Britain’s willingness to fight. This got me thinking: was Coventry some kind of watershed, before which the conflict was of the displacement type, and afterward, of the depopulation type?

The facts bear this out, considering Nazi treatment of the Jews as a litmus test of the zeitgeist of that time. After coming to power in 1933, the Nazis aimed at forcing the Jews to emigrate, and by the outbreak of hostilities in September, 1939, 250,000 of Germany’s 437,000 Jews had done so. The Coventry Blitz was in November, 1940. The Holocaust began, in terms of men, women, and children all being targeted for execution, in August, 1941, nine months later. The German zeitgeist, and perhaps that of the world, seems to have shifted gears in the fall of 1940, aiming at depopulation rather than displacement. I am obviously assuming that the evolutionary, selectionist justification of the Holocaust given at the time, in forums such as the 1942 Wannsee conference, was a rationalization.

I conjecture that wars brought on by population pressure begin as the displacement type, and if this does not result in sufficient local reduction in population pressure after a certain time, the hostilities shift gears to the depopulation type of conflict. If human population is under PID [proportional-integral-differential] control by the subconscious, the event causing the shift could be the amount of signal accumulated on the integrator rising above some threshold. This may actually be a second threshold, with the first and lower threshold controlling the outbreak of a war of displacement.

A paradoxical outcome of Calhoun's overpopulation experiments on rodents can be explained in terms of such an integrator. By providing unlimited food and water to a founder population of rats or mice, with regular bedding changes and exclusion of predators and parasites, the rodents were allowed to increase their population to fabulous numbers. However, the rodents were given no extra space. As the population soared to incredible densities, all kinds of pathological behaviors appeared along with a great deal of violence. Birth rates plummeted after a "behavioral sink" developed, and remained low, never recovering, as the population decreased all the way to zero.

My interpretation of the behavioral sink is that it is integrator windup, a pathology of humanly engineered PID controllers, and possibly natural ones too. The signal accumulated on the integrator has been building for so long, and the population crash is so sudden, that not enough time is spent at population densities below set point to cancel the "control debt" on the integrator, so it continues to insanely command a zero birth rate even as the population is heading for zero.

George Santayana wrote that "Fanaticism consists of redoubling your efforts when you have forgotten your aim." [source, Wiki quotes, accessed 06-11-2018] Sounds like integrator windup to me.

3-17-2018: To clean up some loose ends, let us postulate a third and highest threshold of the control debt, which, if crossed, leads to the human behavioral sink and the possible destruction of the human race due to essentially psychological causes. In the behavioral sink, I postulate that everyone would be a ZPG fanatic and unable to change without pharmacological help. (Good old booze? May not be that simple.) 

I myself may be a "ZPG fanatic", and produced in exactly this way, because I was born in 1953, just before suburbia became important, and may represent what most people in this country would now be had suburbia not been invented to take down the population pressure. At only 2 months from retirement age, I continue to be a virgin with no plans to change my ways, and I may be a straw in the wind, a harbinger of worse to come.

11-26-2019: I can testify from my own experience that the human behavioral sink is more like passive-aggressive personality disorder than anything else, but with particular attention to punishing the opposite sex by ignoring them.

3-22-2018: Correction: the modern suburbs were invented in London 200 years ago, but underwent explosive growth in North America after WWII. By 1950, half the American population was suburban.